SELECT 
  product_id, 
  feature_id, 
  variant_id 
FROM 
  cscart_product_features_values 
WHERE 
  product_id IN (
    12546, 12548, 12547, 12550, 12549, 12552, 
    12551, 12553
  ) 
  AND feature_id IN (625, 624, 627, 628, 553) 
  AND lang_code = 'en'

Query time 0.00221

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "4.58"
    },
    "table": {
      "table_name": "cscart_product_features_values",
      "access_type": "range",
      "possible_keys": [
        "PRIMARY",
        "fl",
        "lang_code",
        "product_id",
        "fpl",
        "idx_product_feature_variant_id"
      ],
      "key": "PRIMARY",
      "used_key_parts": [
        "feature_id",
        "product_id",
        "variant_id",
        "lang_code"
      ],
      "key_length": "15",
      "rows_examined_per_scan": 8,
      "rows_produced_per_join": 8,
      "filtered": "100.00",
      "using_index_for_skip_scan": true,
      "cost_info": {
        "read_cost": "3.78",
        "eval_cost": "0.80",
        "prefix_cost": "4.58",
        "data_read_per_join": "6K"
      },
      "used_columns": [
        "feature_id",
        "product_id",
        "variant_id",
        "lang_code"
      ],
      "attached_condition": "((`test2_gaseus`.`cscart_product_features_values`.`product_id` in (12546,12548,12547,12550,12549,12552,12551,12553)) and (`test2_gaseus`.`cscart_product_features_values`.`feature_id` in (625,624,627,628,553)) and (`test2_gaseus`.`cscart_product_features_values`.`lang_code` = 'en'))"
    }
  }
}